Solubility is a property of interest in many aspects of science, including but not limited to: environmental predictions, biochemistry, pharmacy, drug-design, agrochemical design, and protein ligand binding. Aqueous solubility is of fundamental interest owing to the vital biological and transportation functions played by water. In addition, to this clear scientific interest in water solubility and solvent effects; accurate predictions of solubility are important industrially. The ability to accurately predict a molecules solubility represents potentially large financial savings in many chemical product development processes, such as pharmaceuticals.In the pharmaceutical industry, solubility predictions form part of the early stage lead optimisation process of drug candidates. Solubility remains a concern all the way to formulation. A number of methods have been applied to such predictions including quantitative structure–activity relationships (QSAR), quantitative structure–property relationships (QSPR) and data mining. These models provide efficient predictions of solubility and represent the current standard. The draw back such models is that they can lack physical insight. A method founded in physical theory, capable of achieving similar levels of accuracy at an sensible cost, would be a powerful tool scientifically and industrially.